Trip from Perryville, MO to Saint Joseph, MO

Drive Time

7h 5m

Distance

371.9 mi

599 km

Drive Score

9/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$56

one way

Best Time Drive vs Fly

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Perryville, MO

Valeria Boltneva

Saint Joseph, MO

Andrés Oliver Joya Zapata

Trip Overview

Spanning 371.9 miles across the Missouri heartland, this trek from Perryville to Saint Joseph typically takes about 7 hours and 5 minutes of driving time. While it is technically feasible to complete this journey in a single day, the duration makes for a long stint behind the wheel, so prepare accordingly. You will primarily navigate via the Dwight D. Eisenhower Highway, I-55, and the U.S. Submarine Veterans' Memorial Highway. Budgeting roughly $56 for fuel is a smart way to keep your trip planning on track. Because both your origin and destination are located within the Midwest, you can expect a consistent regional feel throughout the entire excursion.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

2 planned breaks

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

186 miles from Perryville, MO

A natural place for your longest stop of the day , about 3h 40m into the drive .

Drive Character

This trip offers a mixed driving profile, balancing high-speed interstate travel with more varied road types. With highway travel accounting for 34% of the route, you will experience a shift between bustling main corridors and smaller segments. You should be prepared for the longest uninterrupted stretch, which covers 80.7 miles along the Dwight D. Eisenhower Highway. As you transition between these different roadway categories, the personality of the drive changes from expansive, fast-paced stretches to more localized, secondary roads. Staying attentive to these shifts in road type will help you maintain a steady pace across the 371.9-mile distance.

Expect a mix of faster highway mileage and slower local approaches near the beginning or end.

There are about 43 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Dwight D Eisenhower Highway is the longest continuous segment at about 80.7 miles.

How Hard Is This Drive?

This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 67.3 miles in.

Route Complexity 10/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 22 significant decision points across 371.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 67.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 67.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 79.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 22 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

67.3 mi into trip | ~1h 17m in

Take the exit toward I 270 West, I 255 East: Kansas City, Chicago

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 196 Toward I 270 West, I 255 East: Kansas City, Chi...

67.6 mi into trip | ~1h 17m in

Keep slight left at fork toward I 270 West: Kansas City

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight left lane. Toward I 270 West: Kansas City

79.9 mi into trip | ~1h 33m in

Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Lo...

80 mi into trip | ~1h 33m in

Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward I 64 West, US 40 West, US 61 North: Went...

105.9 mi into trip | ~2h 5m in | US 40

Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight left lanes. Exit 1A Toward I 70 West, US 40 West: Kansas City

Towns Along This Route

Between Perryville, MO and Saint Joseph, MO, road signs point toward Chicago and Saint Louis.

Chicago

67.3 mi in | ~1h 17m

Saint Louis

79.9 mi in | ~1h 33m

Main Roads

Road	Distance	Duration
Dwight D Eisenhower Highway	80.7 mi	1h 35m
I 55	59.4 mi	1h 4m
U.S. Submarine Veterans' Memorial Highway	54.4 mi	58m
Dwight D. Eisenhower Highway	54.3 mi	58m
I 29	26 mi	27m
Avenue of the Saints	25.4 mi	30m
I 435	20.9 mi	22m
I 270	11.5 mi	14m

Longest stretch: Dwight D Eisenhower Highway — 80.7 mi, about 1h 35m

Turn-by-Turn Driving Directions

Step-by-step road directions between Perryville, MO and Saint Joseph, MO.

Start on South Spring Street

221 ft · 15 sec · South Spring Street

Turn left onto East Saint Joseph Street

365 ft · 16 sec · East Saint Joseph Street

Turn right onto MO B

349 ft · 10 sec · North Main Street

Continue on MO B

0.4 mi · 1 min · North Main Street

Enter roundabout onto US 61

194 ft · 3 sec · North Kingshighway Street

Continue on US 61

2.4 mi · 3 min · North Kingshighway Street

Continue on US 61

2.8 mi · 4 min · North King's Highway

Turn left onto MO M

0.5 mi · 1 min · MO M

Take the ramp

0.2 mi · 27 sec

Toward I 55 North: Saint Louis

Merge onto I 55

59 mi · 1 hr 4 min · I 55

Continue on I 55

1.3 mi · 1 min · Rosa Parks Highway

Use the none lane.

Take the exit

0.2 mi · 27 sec

Exit 196 Toward I 270 West, I 255 East: Kansas City, Chicago Use the slight right lane.

Keep slight left at fork

388 ft · 8 sec

Toward I 270 West: Kansas City Use the slight left lane.

Continue on this road

0.7 mi · 1 min · this road

Exit 196 Toward I 270 West

Merge onto I 270

11 mi · 14 min · I 270

Use the none lane.

Take the exit

0.1 mi · 17 sec

Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Louis Use the slight right lane.

Keep slight left at fork

0.4 mi · 48 sec

Toward I 64 West, US 40 West, US 61 North: Wentzville Use the slight left lane.

Continue on this road

0.1 mi · 9 sec · this road

Exit 12 Toward I 64 West, US 40 West, US 61 North: Wentzville

Merge onto I 64; US 40; US 61

25 mi · 30 min · Avenue of the Saints

Use the straight lane.

Take the exit onto US 40

0.6 mi · 1 min · US 40

Exit 1A Toward I 70 West, US 40 West: Kansas City Use the straight / slight left lanes.

Merge onto I 70; US 40

81 mi · 1 hr 35 min · Dwight D Eisenhower Highway

Continue on I 70; US 40

2.0 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway

Continue on I 70; US 40

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway

Continue on I 70; US 40

1.8 mi · 2 min · Dwight D. Eisenhower Highway

Continue on I 70; US 40

54 mi · 58 min · U.S. Submarine Veterans' Memorial Highway

Continue on I 70; US 40

52 mi · 56 min · Dwight D. Eisenhower Highway

Use the none lane.

Continue on I 70

2.7 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

1.8 mi · 2 min · Clifton J. Scott Memorial Highway

Use the none / straight / slight right lanes.

Continue on I 70

2.9 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

0.8 mi · 58 sec · George Brett Super Highway

Take the exit

1.1 mi · 2 min

Exit 8B Toward I 435 North, US 24 East: Des Moines Use the straight / slight right lanes.

Merge onto I 435; US 24

7.8 mi · 9 min · Lamar Hunt Memorial Highway

Use the none lane.

Continue on I435 N

1.3 mi · 1 min · I435 N

Continue on I 435

21 mi · 22 min · I 435

Use the none lane.

Keep slight left at fork onto I 29; US 71

26 mi · 27 min · I 29; US 71

Toward I 29 North, US 71 North: Saint Joseph Use the none lane.

Take the exit

0.5 mi · 54 sec

Exit 43 Toward I 229 North: Downtown Saint Joseph

Continue on I 229

5.7 mi · 6 min · I 229

Take the exit

0.3 mi · 33 sec

Exit 6A Toward Central Business District

Continue on Edmond Street

0.5 mi · 57 sec · Edmond Street

Turn left onto I 29 Business

0.2 mi · 20 sec · South 10th Street

Turn right onto I 29 Business

379 ft · 6 sec · Frederick Avenue

Turn slight right onto Walter Welsh Avenue

137 ft · 2 sec · Walter Welsh Avenue

Arrive at destination

Walter Welsh Avenue

Trip Plan

To keep your energy high during this 7-hour drive, plan for at least two intentional stops along the way. Leaving early in the morning is your best strategy to avoid fatigue and ensure you reach Saint Joseph before nightfall. Since you are looking at a $56 fuel expense, check your tank levels before hitting the longest 80.7-mile stretch to avoid unnecessary stress in more remote sections. Because this route is designed as a one-day trip, embrace the flexibility of your schedule by choosing your rest stops based on how you feel rather than a rigid timeline. Keeping your pace consistent will make the transition between the Dwight D. Eisenhower Highway and your final destination much smoother.

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.

Plan roughly 2 meaningful breaks for fuel, food, and rest.

The halfway point lands around 186 miles from Perryville, MO, or about 3h 40m into the drive.

The longest continuous stretch on this route runs about 80.7 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 82 miles or 1h 36m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 186 miles or 3h 40m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 5h 58m

Traffic, exits, and arrival timing usually matter more near Saint Joseph, MO than in the middle of the route.

Before You Leave

Open the route before leaving Perryville, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Pick one backup stop option before the midpoint in case traffic changes your pacing.

Day 1

Settle into the route from Perryville, MO

This is one driving day of about 371.9 miles and 7h 5m.

Your first comfortable stop window is around 82 miles from Perryville, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 2 real breaks rather than only quick fuel stops.

The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 186 mi from Perryville, MO · 3h 40m into the drive

Mid-route town

Meal stop

Alton, IL

186 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

East Saint Louis, IL

Fuel and coffee

A short stop after about 82 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 186 miles from Perryville, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Dwight D Eisenhower Highway if your tank is already low. That segment runs about 80.7 miles.

Arriving in Saint Joseph, MO

The final approach into Saint Joseph, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Saint Joseph, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$56.49 one way

$112.98 round trip

$3.86/gal 25.4 MPG avg 130 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.25	$62.27	$124.54
premium	$4.80	$70.21	$140.41
diesel	$5.64	$82.62	$165.25

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$56

Meals

$25–$50

Total

$81–$106

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 130.1 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $39 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	111.6	1	$39.05	$17.85
Efficient EV	93	1	$32.54	$14.88
EV Truck/SUV	148.8	1	$52.07	$23.80

Gas CO2

130 kg

EV CO2

44 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Perryville, MO

Afternoon in Perryville on Sunday

Local time

2:27 PM

CDT

Current temp

79°F

Unavailable

Live forecast

Destination

Saint Joseph, MO

Afternoon in Saint Joseph on Sunday

Local time

2:27 PM

CDT

Current temp

45°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

34 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

7h 5m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Perryville, MO to Saint Joseph, MO covers 371.9 miles and takes about 7h 5m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Dwight D Eisenhower Highway, I 55, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 186 miles from Perryville, MO. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $56.49 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.

Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Between Perryville, MO and Saint Joseph, MO, road signs point toward Chicago and Saint Louis.

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Return Trip

Saint Joseph, MO to Perryville, MO

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371.7 mi 7h 3m

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Trip from Perryville, MO to Saint Joseph, MO

Trip Overview

Drive Character

How Hard Is This Drive?

Critical Maneuvers

Towns Along This Route

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Arriving in Saint Joseph, MO

Fuel & Cost

Travel Intel

Perryville, MO

Saint Joseph, MO

Same local time

34 degrees cooler at arrival

7h 5m on the road

Frequently Asked Questions

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