Origin
Perryville, MO
Afternoon in Perryville on Sunday
Local time
2:28 PM
CDT
Current temp
79°F
Unavailable
Live forecast
Trip from Perryville, MO to East Independence, MO
Drive Time
5h 54m
Distance
304.6 mi
490 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$46
one way
Perryville, MO
Valeria Boltneva
East Independence, MO
Ankit Rainloure
Trip Overview
Connecting Perryville to East Independence, this 304.6-mile trek across the Missouri Midwest is a straightforward journey that takes approximately 5 hours and 54 minutes. Given the duration, it is perfectly suited for a single-day trip, allowing you to reach your destination without needing an overnight stop. Budgeting about $46 for fuel should cover your transit across the state. While the route is manageable in one go, you will want to account for the single stop recommended to keep your energy levels up. Whether you are heading west for business or a visit, this drive offers a reliable connection between two distinct Missouri points.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
152.3 miles from Perryville, MO
A natural place for your longest stop of the day , about 3h into the drive .
Drive Character
Expect a mix of driving styles as you navigate this route, which is characterized as a turn-heavy local drive. You will spend roughly 24% of your time on highways, including the Dwight D. Eisenhower Highway, I-55, and the U.S. Submarine Veterans' Memorial Highway. Your longest uninterrupted stretch occurs on the Dwight D. Eisenhower Highway, spanning 80.7 miles. Because this path isn't a simple, monotonous interstate grind, you should remain alert for shifting road conditions as you transition between major thoroughfares and local segments.
This route has more turning and local-road decision points than a simple highway run.
There are about 35 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D Eisenhower Highway is the longest continuous segment at about 80.7 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 67.3 miles in.
Route Complexity
9/10
High effort - long or complex enough to need steady focus all day
This is a demanding drive. With 22 significant decision points across 304.6 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 67.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 67.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 79.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 22 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
8
67.3 mi into trip
|
~1h 17m in
Take the exit toward I 270 West, I 255 East: Kansas City, Chicago
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 196
Toward I 270 West, I 255 East: Kansas City, Chi...
8
67.6 mi into trip
|
~1h 17m in
Keep slight left at fork toward I 270 West: Kansas City
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 270 West: Kansas City
8
79.9 mi into trip
|
~1h 33m in
Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
80 mi into trip
|
~1h 33m in
Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 64 West, US 40 West, US 61 North: Went...
8
105.9 mi into trip
|
~2h 5m in
|
US 40
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Exit 1A
Toward I 70 West, US 40 West: Kansas City
Towns Along This Route
Between Perryville, MO and East Independence, MO, road signs point toward Chicago and Saint Louis.
Chicago
67.3 mi in
|
~1h 17m
Saint Louis
79.9 mi in
|
~1h 33m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Dwight D Eisenhower Highway | 80.7 mi | 1h 35m |
| I 55 | 59.4 mi | 1h 4m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| Dwight D. Eisenhower Highway | 54.3 mi | 58m |
| Avenue of the Saints | 25.4 mi | 30m |
| I 270 | 11.5 mi | 14m |
| North King's Highway | 2.8 mi | 4m |
| North Kingshighway Street | 2.5 mi | 3m |
Longest stretch:
Dwight D Eisenhower Highway
— 80.7 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Perryville, MO and East Independence, MO.
1
Start on South Spring Street
221 ft
·
15 sec
·
South Spring Street
2
Turn left onto East Saint Joseph Street
365 ft
·
16 sec
·
East Saint Joseph Street
3
Turn right onto MO B
349 ft
·
10 sec
·
North Main Street
4
Continue on MO B
0.4 mi
·
1 min
·
North Main Street
5
Enter roundabout onto US 61
194 ft
·
3 sec
·
North Kingshighway Street
6
Continue on US 61
2.4 mi
·
3 min
·
North Kingshighway Street
7
Continue on US 61
2.8 mi
·
4 min
·
North King's Highway
8
Turn left onto MO M
0.5 mi
·
1 min
·
MO M
9
Take the ramp
0.2 mi
·
27 sec
Toward I 55 North: Saint Louis
10
Merge onto I 55
59 mi
·
1 hr 4 min
·
I 55
11
Continue on I 55
1.3 mi
·
1 min
·
Rosa Parks Highway
Use the none lane.
12
Take the exit
0.2 mi
·
27 sec
Exit 196
Toward I 270 West, I 255 East: Kansas City, Chicago
Use the slight right lane.
13
Keep slight left at fork
388 ft
·
8 sec
Toward I 270 West: Kansas City
Use the slight left lane.
14
Continue on this road
0.7 mi
·
1 min
·
this road
Exit 196
Toward I 270 West
15
Merge onto I 270
11 mi
·
14 min
·
I 270
Use the none lane.
16
Take the exit
0.1 mi
·
17 sec
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Louis
Use the slight right lane.
17
Keep slight left at fork
0.4 mi
·
48 sec
Toward I 64 West, US 40 West, US 61 North: Wentzville
Use the slight left lane.
18
Continue on this road
0.1 mi
·
9 sec
·
this road
Exit 12
Toward I 64 West, US 40 West, US 61 North: Wentzville
19
Merge onto I 64; US 40; US 61
25 mi
·
30 min
·
Avenue of the Saints
Use the straight lane.
20
Take the exit onto US 40
0.6 mi
·
1 min
·
US 40
Exit 1A
Toward I 70 West, US 40 West: Kansas City
Use the straight / slight left lanes.
21
Merge onto I 70; US 40
81 mi
·
1 hr 35 min
·
Dwight D Eisenhower Highway
22
Continue on I 70; US 40
2.0 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
23
Continue on I 70; US 40
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
24
Continue on I 70; US 40
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
25
Continue on I 70; US 40
54 mi
·
58 min
·
U.S. Submarine Veterans' Memorial Highway
26
Continue on I 70; US 40
52 mi
·
56 min
·
Dwight D. Eisenhower Highway
Use the none lane.
27
Take the exit
0.3 mi
·
40 sec
Exit 17
Toward Little Blue Parkway, 39th Street, Mall Entrance
Use the slight right lane.
28
Turn right onto South Little Blue Parkway
1.6 mi
·
3 min
·
South Little Blue Parkway
29
Turn left onto East R.D. Mize Road
0.2 mi
·
37 sec
·
East R.D. Mize Road
30
Turn right onto South Jackson Drive
1.2 mi
·
2 min
·
South Jackson Drive
31
Turn straight onto Holke Road
0.9 mi
·
2 min
·
Holke Road
32
Turn left onto East Truman Road
0.7 mi
·
1 min
·
East Truman Road
33
Turn right onto Main Road
0.3 mi
·
1 min
·
Main Road
34
Turn right onto East 9th Street South
79 ft
·
3 sec
·
East 9th Street South
35
Arrive at destination
East 9th Street South
Trip Plan
To make the most of your 6-hour drive, try to depart early in the morning to avoid midday traffic congestion. Plan your single stop strategically near the halfway point to break up the turn-heavy sections and give yourself a chance to stretch. Keep an eye on your fuel gauge, especially when transitioning off the main highway stretches, and ensure your $46 gas budget is easily accessible. Since this is a one-day trip, use your flexibility to adjust your pace based on real-time traffic updates. Prioritize safety during the technical segments by maintaining a steady speed through the more winding portions of the local roads.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 152.3 miles from Perryville, MO, or about 3h into the drive.
The longest continuous stretch on this route runs about 80.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 33m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 152.3 miles or 3h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 49m
Traffic, exits, and arrival timing usually matter more near East Independence, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Perryville, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Perryville, MO
This is one driving day of about 304.6 miles and 5h 54m.
Your first comfortable stop window is around 80 miles from Perryville, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 152.3 mi from Perryville, MO · 3h into the drive
Mid-route town
Meal stop
152 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 152.3 miles from Perryville, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D Eisenhower Highway if your tank is already low. That segment runs about 80.7 miles.
Arriving in East Independence, MO
The final approach into East Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around East Independence, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$46.27 one way
$92.53 round trip
$3.86/gal
25.4 MPG avg
107 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $51.00 | $102.01 |
| premium | $4.80 | $57.50 | $115.00 |
| diesel | $5.64 | $67.67 | $135.34 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 106.6 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $32 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 91.4 | 1 | $31.98 | $14.62 |
| Efficient EV | 76.2 | 0 | $26.65 | $12.18 |
| EV Truck/SUV | 121.8 | 1 | $42.64 | $19.49 |
Gas CO2
107 kg
EV CO2
36 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
East Independence, MO
Afternoon in East Independence on Sunday
Local time
2:28 PM
CDT
Current temp
49°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
30 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 54m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Perryville, MO to East Independence, MO covers 304.6 miles and takes about 5h 54m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D Eisenhower Highway, I 55, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 152.3 miles from Perryville, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $46.27 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 22 significant decision points across 304.6 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 67.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 67.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 79.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Perryville, MO and East Independence, MO, road signs point toward Chicago and Saint Louis.
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Return Trip
East Independence, MO to Perryville, MOPlan the drive back the other way.
304.4 mi
5h 53m
Continue From East Independence, MO
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