Origin
Perryville, MO
Afternoon in Perryville on Wednesday
Local time
4:57 PM
CDT
Current temp
56°F
Unavailable
Last recalculated Apr 15, 2026
Drive Time
6h 20m
Distance
327 mi
526 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$51
one way
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Perryville, MO
Wikimedia Commons
Joplin, MO
Wikimedia Commons
The drive from Perryville, MO to Joplin, MO covers 327 miles and takes about 6h 20m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 44, I 55, MO 30 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 222.8 miles on I 44. At current regular gas prices, budget about $51.12 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
163.5 miles from Perryville, MO
A natural place for your longest stop of the day , about 3h 15m into the drive .
This is a 6h 20m highway drive covering 327 miles, with most of the trip on I 44 and I 55. The longest continuous stretch is about 222.8 miles on I 44.
This is a straightforward highway drive that stays mostly on I 44 and I 55. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near East Saint Joseph Street.
Easy - simple navigation with a manageable amount of wheel time
The route itself is not hard, but at 6h 20m, endurance matters. Plan breaks every 2-3 hours. The 16 decision points are all manageable with basic attention.
Where does it get tricky?
The main spots that need attention: near the start (East Saint Joseph Street): Navigation decision point; at 0.6 miles (US 61 / North Kingshighway Street): Roundabout - know your exit number before entering; at 55.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
These are the spots where you need to pay the most attention. Preview them before you drive.
Turn left onto East Saint Joseph Street
Navigation decision point
Enter roundabout onto US 61 / North Kingshighway Street
Roundabout - know your exit number before entering
Take the exit toward MO M: Antonia, Barnhart
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Take the exit toward I 44 West: Rolla
Exit ramp - move to the correct lane early
Take the exit onto I 44 Business; MO 66 toward I 44 Business, MO 66: Duenweg, Joplin
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Perryville, MO and Joplin, MO, road signs point toward Mo M: Antonia and Barnhart.
Mo M: Antonia
Barnhart
| Road | Distance | Duration |
|---|---|---|
| I 44 | 222.8 mi | 4h |
| I 55 | 49.2 mi | 52m |
| MO 30 | 27 mi | 38m |
| MO M | 12.3 mi | 19m |
| I 44 Business | 8.5 mi | 17m |
| North King's Highway | 2.8 mi | 4m |
| North Kingshighway Street | 2.5 mi | 3m |
| North Main Street | 0.5 mi | 1m |
Step-by-step road directions between Perryville, MO and Joplin, MO.
Start on South Spring Street
Turn left onto East Saint Joseph Street
Turn right onto MO B
Continue on MO B
Enter roundabout onto US 61
Continue on US 61
Continue on US 61
Turn left onto MO M
Take the ramp
Merge onto I 55
Take the exit
At end of road, turn left onto MO M
Turn left onto MO 30
Continue on US Historic 66; MO 30
Turn right onto US Historic 66; MO 30
Take the exit
Merge onto I 44
Take the exit onto I 44 Business; MO 66
Turn right onto US Historic 66; MO 43
Turn right
Turn right
Arrive at destination
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 72 miles or 1h 28m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 163.5 miles or 3h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 8m
Traffic, exits, and arrival timing usually matter more near Joplin, MO than in the middle of the route.
Open the route before leaving Perryville, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Perryville, MO
This is one driving day of about 327 miles and 6h 20m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 163.5 mi from Perryville, MO · 3h 15m into the drive
Mid-route town
Meal stop
164 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 72 miles helps settle the day before fatigue starts building.
The midpoint is around 163.5 miles from Perryville, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 44 if your tank is already low. That segment runs about 222.8 miles.
The final approach into Joplin, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Joplin, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$51.12 one way
$102.25 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $56.13 | $112.26 |
| premium | $4.89 | $62.93 | $125.86 |
| diesel | $5.61 | $72.20 | $144.39 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$51
Meals
$25–$50
Total
$76–$101
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 114.4 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 98.1 | 1 | $34.33 | $15.70 |
| Efficient EV | 81.8 | 0 | $28.61 | $13.08 |
| EV Truck/SUV | 130.8 | 1 | $45.78 | $20.93 |
Gas CO2
114 kg
EV CO2
38 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Current conditions at both ends of the drive.
Origin
Afternoon in Perryville on Wednesday
Local time
4:57 PM
CDT
Current temp
56°F
Unavailable
Destination
Afternoon in Joplin on Wednesday
Local time
4:57 PM
CDT
Current temp
57°F
Unavailable
57°F
Chesterfield, MO
164 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
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