Trip from Kansas City, MO to Perryville, MO

Drive Time

6h 1m

Distance

313.9 mi

505 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$48

one way

Best Time Drive vs Fly

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Photo: Valeria Boltneva

Trip Overview

Connecting Kansas City to Perryville, this 313.9-mile journey across Missouri takes approximately 6 hours and 1 minute of driving time. Because the route is categorized as a turn-heavy local drive, it is best suited for a single-day trip if you are comfortable with a full day behind the wheel. You should budget about $48 for fuel to complete the trek between these two Midwest locations. While the trip is manageable in one go, you will need to account for at least one planned stop to maintain your energy. It is a straightforward transit across the state, perfect for travelers who want to get from the western edge to the eastern side of Missouri efficiently.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

157 miles from Kansas City, MO

A natural place for your longest stop of the day , about 2h 56m into the drive .

Drive Character

Expect a varied experience as you transition from major thoroughfares to more localized roads. Only 5% of this journey is spent on major highways, meaning you will spend the vast majority of your time navigating secondary routes. The longest uninterrupted section spans 135.3 miles along the Dwight D. Eisenhower Highway, providing a significant stretch of consistent driving. Following that, you will navigate segments of the Police Officer Steven Jarvis Memorial Highway and the U.S. Submarine Veterans' Memorial Highway. Prepare for a turn-heavy environment that demands more attention than a typical interstate grind, as the road profile shifts significantly from high-speed corridors to local navigation.

This route has more turning and local-road decision points than a simple highway run.

There are about 33 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Dwight D. Eisenhower Highway is the longest continuous segment at about 135.3 miles.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near East 12th Street.

Route Complexity 10/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 19 significant decision points across 313.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: near the start (East 12th Street): Navigation decision point; at 208.1 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 233.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 19 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

0 mi into trip | ~0m in | East 12th Street

Turn right onto East 12th Street

Navigation decision point

208.1 mi into trip | ~3h 56m in | US 40

Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield

Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one

Exit 210A Toward I 64 East, US 40 East, US 61 South: Ches...

233.5 mi into trip | ~4h 27m in

Take the exit toward I 270: Chicago, Memphis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 25 Toward I 270: Chicago, Memphis

233.8 mi into trip | ~4h 27m in

Keep slight right at fork toward I 270 South: Memphis

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight right lane. Toward I 270 South: Memphis

245.6 mi into trip | ~4h 42m in

Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Exit 1A Toward I 55, US 61, US 67: Saint Louis, Memphis...

Towns Along This Route

On the drive from Kansas City, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.

Memphis

233.5 mi in | ~4h 27m

Main Roads

Road	Distance	Duration
Dwight D. Eisenhower Highway	135.3 mi	2h 34m
Police Officer Steven Jarvis Memorial Highway	57.5 mi	1h 1m
U.S. Submarine Veterans' Memorial Highway	54.4 mi	58m
Avenue of the Saints	25.1 mi	30m
I 270	11.5 mi	14m
George Brett Super Highway	6.9 mi	9m
Truman/Eisenhower Presidential Highway	5.6 mi	6m
US 61	5.3 mi	7m

Longest stretch: Dwight D. Eisenhower Highway — 135.3 mi, about 2h 34m

Turn-by-Turn Driving Directions

Step-by-step road directions between Kansas City, MO and Perryville, MO.

Start on Oak Street

20 ft · 4 sec · Oak Street

Turn right onto East 12th Street

0.2 mi · 42 sec · East 12th Street

Turn right onto Charlotte Street

476 ft · 11 sec · Charlotte Street

Take the ramp

0.2 mi · 28 sec

Toward I 70 East, US 40 East

Merge onto I 70; US 24; US 40

6.9 mi · 9 min · George Brett Super Highway

Use the none lane.

Continue on I 70

2.9 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

1.8 mi · 2 min · Clifton J. Scott Memorial Highway

Use the none / straight / slight right lanes.

Continue on I 70

2.6 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

53 mi · 56 min · Dwight D. Eisenhower Highway

Use the none lane.

Continue on I 70; US 40

32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway

Keep slight left at fork onto I 70

22 mi · 24 min · U.S. Submarine Veterans' Memorial Highway

Continue on I 70; US 40

1.8 mi · 2 min · Dwight D. Eisenhower Highway

Continue on I 70; US 40

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway

Continue on I 70; US 40

1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway

Continue on I 70; US 40

81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway

Take the exit onto US 40

0.3 mi · 33 sec · US 40

Exit 210A Toward I 64 East, US 40 East, US 61 South: Chesterfield

Merge onto I 64; US 40; US 61

25 mi · 30 min · Avenue of the Saints

Use the straight / slight left lanes.

Take the exit

0.3 mi · 38 sec

Exit 25 Toward I 270: Chicago, Memphis Use the slight right lane.

Keep slight right at fork

0.3 mi · 31 sec

Toward I 270 South: Memphis Use the slight right lane.

Merge onto I 270

11 mi · 14 min · I 270

Use the none lane.

Take the exit

0.4 mi · 27 sec

Exit 1A Toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road Use the straight / slight right lanes.

Keep slight right at fork

0.4 mi · 43 sec

Toward I 55 South: Memphis

Merge onto I 55

1.5 mi · 1 min · Rosa Parks Highway

Use the none lane.

Continue on I 55

1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway

Use the none lane.

Continue on I 55

57 mi · 1 hr 1 min · Police Officer Steven Jarvis Memorial Highway

Use the none lane.

Take the exit

0.2 mi · 29 sec

Exit 135 Toward MO M: Brewer

Turn left onto MO M

0.6 mi · 1 min · MO M

At end of road, turn right onto US 61; MO M

5.3 mi · 7 min · US 61; MO M

Enter roundabout onto MO B

55 ft · 0 sec · North Main Street

Continue on MO B

0.5 mi · 1 min · North Main Street

Turn left onto East Saint Joseph Street

365 ft · 18 sec · East Saint Joseph Street

Turn right onto South Spring Street

221 ft · 9 sec · South Spring Street

Arrive at destination

South Spring Street

Trip Plan

To make the most of this 6-hour drive, try departing early in the morning to beat local traffic patterns and ensure you arrive in Perryville before sunset. Since you will be navigating a route with significant turn-heavy sections, keep your navigation system updated to avoid missing key exits on the memorial highways. Factor in at least one substantial break to stretch your legs, especially given the technical nature of the local road segments. With a $48 fuel estimate, consider topping off your tank before leaving Kansas City to avoid unnecessary stops during the longest 135.3-mile stretch. Flexibility is your biggest advantage here, so use your single planned stop strategically to break up the monotony of the winding local roads.

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 157 miles from Kansas City, MO, or about 2h 56m into the drive.

The longest continuous stretch on this route runs about 135.3 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 29m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 157 miles or 2h 56m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 56m

Traffic, exits, and arrival timing usually matter more near Perryville, MO than in the middle of the route.

Before You Leave

Open the route before leaving Kansas City, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Kansas City, MO

This is one driving day of about 313.9 miles and 6h 1m.

Your first comfortable stop window is around 80 miles from Kansas City, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 157 mi from Kansas City, MO · 2h 56m into the drive

Mid-route town

Meal stop

Alton, IL

157 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Quincy, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 157 miles from Kansas City, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 135.3 miles.

Arriving in Perryville, MO

The final approach into Perryville, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Perryville, MO.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$47.68 one way

$95.36 round trip

$3.86/gal 25.4 MPG avg 110 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.25	$52.56	$105.12
premium	$4.80	$59.26	$118.52
diesel	$5.64	$69.74	$139.48

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$48

Meals

$25–$50

Total

$73–$98

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 109.8 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $33 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	94.2	1	$32.96	$15.07
Efficient EV	78.5	0	$27.47	$12.56
EV Truck/SUV	125.6	1	$43.95	$20.09

Gas CO2

110 kg

EV CO2

37 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Kansas City, MO

Afternoon in Kansas City on Sunday

Local time

1:38 PM

CDT

Current temp

49°F

Unavailable

Live forecast

Destination

Perryville, MO

Afternoon in Perryville on Sunday

Local time

1:38 PM

CDT

Current temp

79°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

30 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

6h 1m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Kansas City, MO to Perryville, MO covers 313.9 miles and takes about 6h 1m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Dwight D. Eisenhower Highway, Police Officer Steven Jarvis Memorial Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 157 miles from Kansas City, MO. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $47.68 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

On the drive from Kansas City, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.

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Return Trip

Perryville, MO to Kansas City, MO

Plan the drive back the other way.

314.3 mi 6h 2m

Explore more options from Kansas City, MO or browse trips ending in Perryville, MO.

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Trip from Kansas City, MO to Perryville, MO

Trip Overview

Drive Character

How Hard Is This Drive?

Critical Maneuvers

Towns Along This Route

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Arriving in Perryville, MO

Fuel & Cost

Travel Intel

Kansas City, MO

Perryville, MO

Same local time

30 degrees warmer at arrival

6h 1m on the road

Frequently Asked Questions

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